Birus- the intelligently designed bacteria that may kill covid-19

 

Birus- the intelligently designed bacteria that may kill covid-19

Steve Ramsey,PhD -Public Health MSc(hon) in Med Ultrasound

Steve Ramsey,PhD -Public Health MSc(hon) in Med Ultrasound

I called the new agent BIRUS , as in the future we may see bacteria that infected with virus and helping it to get to our system in return that the virus will provide some help to the host bacteria BIRUS will be difficult to treat as it will be like a superbug and antibiotics will not be effective to destroy it. It will be like super virus .This is my brainstorming ideas that opened for discussion as I am not a virologist nor bacteriologist but did lots of work in infection control and studied viruses and bacteria along with many other agents while doing my PhD in health science ,public health and epidemiology.

Opened for any comment to discuss and increase our knowledge to fight this evil virus.The evolutionary history of viruses represents a fascinating, albeit murky, topic for virologists and cell biologists. Because of the great diversity among viruses, biologists have struggled with how to classify these entities and how to relate them to the conventional tree of life. They may represent genetic elements that gained the ability to move between cells.

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They may represent previously free-living organisms that became parasites. They may be the precursors of life as we know it. A virus is a small parasite that cannot reproduce by it. Once it infects a susceptible cell, however, a virus can direct the cell machinery to produce more viruses.

Most viruses have either RNA or DNA or  as their genetic material. The nucleic acid may be single or double-stranded. The entire infectious virus particle, called a viron, consists of the nucleic acid and an outer shell of protein. The simplest viruses contain only enough RNA or DNA to encode four proteins. The most complex can encode 100 – 200 proteins.

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Any of the microbes that make us sick can live on hard surfaces for up to four or five days. When we touch those surfaces, the microbes can make it into our bodies through our nose, mouth, or eyes, and infect us.

On copper surfaces, bacteria and viruses die. When a microbe lands on a copper surface the copper releases ions, which are electrically charged particles. Those copper ions blast through the outer membranes and destroy the whole cell, including the DNA or RNA inside. Because their DNA and RNA are destroyed, it also means a bacteria or virus can’t mutate and become resistant to the copper, or pass on genes (like for antibiotic resistance) to other microbes. This could be a great idea to make sure that water filters and certain areas in the hospitals will be made of Copper.Many places in the world like in the USA and japan are using copper for pipes and plumbing.

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It is possible to develop an anti-covid-19 therapeutic based on bacteria.

Mycobacterium bacterial species could be a model for such an approach as these bacteria can enter immune cells. Perhaps this could be an application for a synthetically engineered bacterium that can eat copper ions and can kill the virus this is just my brainstorming idea.

The bacteria would be engineered to display covid-19 receptors bacterial surface. This would enable the bacteria to absorb free covid-19 viral particles then the copper ion can destroy it .The same displayed covid-19 receptors could be designed to govern bacterial attachment and entry into virus infected human cells that which display covid-19 envelope proteins. The bacteria could then be engineered to kill cells infected with covid-19 again this is just my Idea for the bio-pharmacology-viral bacterial researchers can design.

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This designed bacteria based antiviral therapeutic would be self replicating. But maybe would work an intracellular bacteria and tissue specific that block the viral replication mechanisms design by synthetic biology “decoy bacteria”.

The researchers have to understand of course that the T lymphocytes, that’s a pretty narrow host range and it clearly has very specific targeting requirements. Not to mention that bacterial cell walls are completely different than the plasma membrane of human cells.

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Not only are restriction enzymes used by bacteria to degrade foreign DNA, but you should also research about the CRISPR/Cas adaptive immune system in bacteria, which works via a guide RNA to target foreign (phage or plasmid, usually) DNA for destruction – sort of like RNAi but with a DNA target.

 These systems have actually been reconstituted in mammalian cells and so could potentially destroy the covid-19 genome in any engineered cell type you want. The question is how we can feed copper ion to the host bacteria? My answer is simple just like Iron attracted to magnet the copper attracts to sulfurs and phosphorous and it is easy for a chemist to find which chemical can attract to copper so we have to start with them then introduce the copper.

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Another Idea we know the covid-19 virus contains lots of fat in its structure to protected from cold, so if the virus have fat the copper will love that as Copper.

Can interact with lipids and fat cells causing their per oxidation and opening holes in the cell membranes, thereby compromising the integrity of cells. Just like a ball, driven into the goal, causing the net to bulge out and wrap itself closely around the leather: This is how it appears when some virus like covid-19 penetrates into a cell. The virus docks onto the cell membrane, which in turn invigilates deeply, wraps itself tightly around the intruder and buds into a vesicle that is finally pinched off inside the cell by using its fat to initiate communication.

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A virus is a small infectious agent that replicates only inside the living cells of an organism. Viruses can infect all types of life forms, from animals and plants to microorganisms, including bacteria and archaea, if we have intelligently designed bacteria that impregnated with copper ions and allow the covid-19 receptor to attach then the copper ion can zap the virus DNA and destroy the fat and kill the virus.

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Viruses are utilizing bacterial components to enter target cells, while bacteria capitalize on the destructive nature of virus replication to gain footholds into previously inaccessible regions. Throughout the body these microorganisms can collaborate to better each other, to the detriment of the host. Further elucidation and discovery of virus-bacteria relationships and mechanisms involved in infection is crucial.

Although technically challenging, such advancement may r enquire development or improvement of new in vitro or in vivo models. Certainly, advances in metagenomics and the microbiome will play an important role in better understanding these environments and interactions. By focusing on microbial interactions instead of solely on the causative disease agent, it may be possible to exploit these pathways in an effort to identify new therapeutic targets.

Contemplating the origins of life fascinates both scientists and the general public. Understanding the evolutionary history of viruses may shed some light on this interesting topic. To date, no clear explanation for the origin(s) of viruses exists.

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When we’re sick because of a bacterial infection, how do we attack and kill the bacteria? The simple answer is to use antibiotics prescribed by our doctor. Sometimes, it so happens that due to the frequent use of antibiotics, the bacteria develop immunity and refuse to die, so we continue to remain sick. Now, think of our unlikely hero the bacteriophage! The primary role of a bacteriophage is to eat/kill the bad bacteria! Imagine the role a bacteriophage could play in treating human diseases! This approach to health is also referred to as phage therapy. We can design smart micro bacteriophage that impregnated with copper ion and other chemicals with new receptors match tocovid-19 to destroy it. 

Steve Ramsey, PhD-Public Health. MSc medical Ultrasound.

Okotoks -Alberta – Canada.

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